The main goal of the Fridman lab is to gain new insights into the biological activities of antimicrobial agents and discover novel concepts for their development with the focus on antifungal agents. Pathogenic fungi pose a major global clinical challenge, placing them as high priority targets for current drug development. Unlike bacteria, fungi are eukaryotes, and intracellular drug targets reside within different organelles, which limits drug-target interactions. We use synthetic modifications to localize an antifungal drug to the organelle that harbors its target, thereby improving efficacy by increasing the drug’s local concentration in the organelle where its target resides. Using fluorescent antifungal agents and spatio-temporal live cell fluorescent imaging we uncover patterns of molecular descriptors that determine the uptake and subcellular distribution of antifungals and to learn how antifungal drug resistance, tolerance, and mode/s of action are affected by subcellular distribution.
NEWS & UPDATES
January 20, 2024
Congratulations to Moriah and to our collaborators for the publication of our manuscript entitled Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point-Mutation-Mediated Resistance