top of page
Webstite background 3.tif

Publications

PEER-REVIEWED MANUSCRIPTS

2026

76. Fluorescent Farnesyl-Derived Probes Reveal Distinct Intracellular Localization Associated with Morphogenesis Suppression in Candida albicans.  Voronov, Ivan; Shbeta, Melissa;   Fridman, Micha. ACS Infectious Diseases, 2026. In Press. 

TOC.png

75. Fluorescent Probes Derived from Clinically Used Polyene Antifungals Reveal Distinct Subcellular Localization Patterns and Elevated Vacuolar Sequestration in Resistant Candida Yeast. Shbeta, Melissa; Kopp, Tal; Voronov, Ivan; Yona, Adi, Afana, Hasib Rania; Carmeli Shmuel; Fridman, Micha. Angewandte Chemie International Edition, 2026, e21135. 

TOC.tif

2025

74. Illuminating antifungal mode of action and resistance with fluorescent probes. Jospe Kaufman, Moriah;  Fridman, Micha. Current Opinion in Chemical Biology, 2025, 85,102570.

2024

73. Chiral Fluorescent Antifungal Azole Probes Detect Resistance, Uptake Dynamics, and Subcellular Distribution in Candida Species. Koren, Vlad; Ben-Zeev, Efrat;  Voronov, Ivan;  Fridman, Micha. JACS Au, 2024, 4, 8, 3157–3169.

TOC 2.6 (5).tiff

72. Boosting Chemiexcitation of Phenoxy-1, 2-dioxetanes through 7-Norbornyl and Homocubanyl Spirofusion. Gutkin, Sara; Shelef, Omri; Babjaková, Zuzana;   Tomanová,Laura Anna; Babjak, Matej;  Kopp, Tal; Zhou, Qingyang;  Ma, Pengchen; Fridman, Micha; Spitz, Urs; Houk, Kendall N.; Shabat, Doron. JACS Au, 2024, 4, 9, 3558–3566.

images_large_au4c00493_0007.jpeg

71. Chemiexcitation Acceleration of 1, 2-Dioxetanes via a Spiro-Fused Inductive Electron-Withdrawing Motifs. David, Maya;  Thomas Leirikh, Thomas; Shelef, Omri; Gutkin, Sara; Kopp, Tal; Zhou, Qingyang; Ma, Pengchen; Fridman, Micha; Houk, Kendall; Shabat, Doron. Angewandte Chemie International Edition, 2024, doi.org/10.1002/anie.202410057.

TOC Corrected PNG (1).png

70. Hyper-Responsive Chemiluminescent Probe Reveals Distinct PYRase Activity in Pseudomonas aeruginosa. Tannous, Rozan; Shelef, Omri; Kopp, Tal; Fridman, Micha; Shabat, Doron. Bioconjugate Chemistry, 2024, 35, 4, 472–479.

images_large_bc4c00015_0005.jpeg

69. Poacic Acid, a Plant-Derived Stilbenoid, Augments Cell-Wall Chitin Production, but Its Antifungal Activity Is Hindered by this Polysaccharide and by Fungal Essential Metals. Yona, Adi; Fridman, Micha. Biochemistry, 2024, 63, 8, 1051–1065.

68. Enzymatic Activity Profiling Using an Ultra-Sensitive Array of Chemiluminescent Probes for Bacterial Classification and Characterization. Shelef, Omri; Kopp, Tal; Tannous, Rozan; Arutkin, Maxence; Jospe-Kaufman, Moriah;  Reuveni, Shlomi; Shabat, Doron; Fridman, Micha. Journal of the American Chemical Society, 2024, 146, 8, 5263–5273.

67. Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point-Mutation-Mediated Resistance.  Jospe-Kaufman, Moriah; Ben-Zeev, Efrat; Mottola, Austin; Dukhovny, Anna; Berman, Judith; Carmeli, Shmuel; Fridman, Micha. Angewandte Chemie International Edition, 2024, 63, 9, e202314728. 

TOC.jpg

2023

66. Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays. Tannous, Rozan; Shelef, Omri; Gutkin, Sara; David, Maya; Leirikh, Thomas; Liang, Ge; Jaber, Qais Z.; Zhou, Qingyang; Ma, Pengchen; Fridman, Micha; Spitz, Urs; Houk, Kendall N.; Shabat Doron. ACS Central Science, 2023, 10, 1, 28–42.

65. Chemiluminescent Duplex Analysis by Phenoxy-1,2-Dioxetane Luminophores with Color Modulation. Gutkin, Sara; Tannous, Rozan Jaber, Qais Z.; Fridman, Micha; Shabat Doron. Chemical Science, 2023, 14, 6953 - 6962.

TOC Figure2.png

64. Dual Chemiexcitation by a Unique Dioxetane Scaffold Gated by an OR Logic Set of Triggers. David, Maya; Jaber, Qais Z.; Fridman, Micha; Shabat Doron. Chemistry, A European Journal, 2023, 29, 25, e202300422.

148.webp

63. Deciphering the Biological Activities of Antifungal Agents with Chemical Probes. Fridman, Micha; Sakurai, Kaori. Angewandte Chemie International Edition , 2023,  62,12,  e202211927.

Picture1.jpg

2022

62. Cationic, Steroid-Based Imidazolium Amphiphiles Show Tunable Backbone-Dependent Membrane Selectivity in Fungi. Wagner, Tristan; Elias, Rebecca; Roling Lena; Raj, Nikita; Gerke, Volker; Fridman, Micha; Glorius, Frank . ACS Infectious Diseases, 2022, 8, 9, 1815–1822.

images_large_id2c00164_0007.jpeg

61. Echinocandins Localized to the Target-Harboring Cell Surface Are Not Degraded but Those Entering the Vacuole Are.  Jaber, Qais Z.; Logviniuk, Dana; Yona, Adi; Fridman, Micha. ACS Chemical Biology, 2022, 17, 5, 1155–1163.

TOC.tif

60. Benzylic Dehydroxylation of Echinocandin Antifungal Drugs Restores Efficacy against Resistance Conferred by Mutated Glucan Synthase.  Logviniuk, Dana; Jaber, Qais Z.; Dobrovetsky, Roman; Kozer, Noga; Ksiezopolska, Ewa; Gabaldón, Toni; Carmeli, Shmuel; Fridman, Micha. Journal of the American Chemical Society, 2022, 144 (13), 5965–5975.

TOC artwork.tif

59. Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles.  Elias, Rebeca; Basu, Pallabita; Fridman, Micha. Journal of Medicinal Chemistry, 2022, 65 (3), 2361-2373.

TOC.tif

2021

58. Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin. Ana  Colabardini, Cristina;  Wang, Fang;  Dong, Zhiqiang; Pardeshi, Lakhansing;  Campos Rocha, Marina; Henrique Costa, Jonas; dos Reis, Fernanda; Brown, Alec; Jaber, Qais Z.; Fridman, Micha; Fill, Taicia;  Rokas, Antonis; Malavazi, Iran; Wong, Koon Ho;  Henrique Goldman, Gustavo.  Genetics, 2021, 220(1), iyab183.

57. Azide‐Functionalized Derivatives of the Virulence‐Associated Sugar Pseudaminic Acid: Chiral Pool Synthesis and Labeling of Bacteria. Vibhute, Amol M.; Tamai, Hideki;  Logviniuk, Dana; Jones, Peter J.; Fridman, Micha; Werz, Daniel B. Chemistry A European Journal, 2021, 27 (41), 10595-10600.

TOC final.tiff

56. Design Guidelines for Cationic Pillar[n]arenes that Prevent Biofilm Formation by Gram-Positive Pathogens. Kaizerman-Kane, Dana; Hadar, Maya; Josef, Roymon; Logviniuk, Dana; Fridman, Micha; Yoram Cohen. ACS Infectious Diseases, 2021, 7 (3) 579–585.

TOC ACS INF 2021.png

55. Fresh Molecular Concepts to Extend the Lifetimes of Old Antimicrobial Drugs. Jaber, Qais, Z.;  Fridman, Micha. The Chemical Record, 2021, 21, 1–16.

54. Combining Colistin and Fluconazole Synergistically Increases Fungal Membrane Permeability and Antifungal Cidality. Bibi, Maayan; Murphy, Sarah; Benhamou, Raphael I.; Rozenberg, Alex; Ulman, Adi; Bicanic, Tihana; Fridman, Micha; Judith Berman. ACS Infectious Diseases, 2021, 7 (2), 377–389.

TOC.png

53. Luminescent Amphiphilic Aminoglycoside Probes for Study of Transfections.   Zimmermann, Alexander; Jaber, Qais Z.;  Koch, Johannes;  Riebea, Steffen; Valletc, Cecilia; Lozae,  Kateryna; Hayduka, Matthias; Steinbuch, Kfir B. Shirley K. Knauerc; Fridman, Micha;  Voskuhl, Jens. ChemBioChem, 2021, 22, 1-6.

2020

52. Serum Prevents Interactions between Antimicrobial Amphiphilic Aminoglycosides and Plasma Membranes.   Logviniuk, Dana; Fridman, Micha. ACS Infectious Diseases,  2020, 12, 3212-3223.

1.tif

51. Elevated Vacuolar Uptake of Fluorescently Labeled Antifungal Drug Caspofungin Predicts Echinocandin Resistance in Pathogenic Yeast. Jaber, Qais Z; Bibi, Maayan; Ksiezopolska, Ewa; Gabaldon, Toni; Berman, Judith; Fridman, Micha. ACS Central Science, 2020, 6, 1698-1712.

1.jpeg

50. The Relationship Between the Structure and Toxicity of aminoglycoside antibiotics. Jospe-Kaufman, Moriah; Siomin, Liza; Fridman, Micha. Bioorganic & Medicinal Chemistry Letters, 2020, 30, 1-5. 

2.jpg

49. Bromopyrrole Alkaloids of the Sponge Agelas oroides Collected Near the Israeli Mediterranean Coastline.  Kovalerchik, Dimitry; Pal Singh, Ravindra; Schlesinger, Pnina; Shefer, Sigal; Fridman, Micha; Ilan, Micha; Carmeli, Shmuel. Journal of Natural Products, 2020, 83, 374-384.

3.jpeg

48. Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics. Louzoun Zada, Sivan; Ben Baruch, Bar; Simhaev, Luba; Engel, Hamutal; Fridman, Micha. Journal of the American Chemical Society, 2020, 142, 3077-3087.

5.jpeg

2019

47. Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. Elias, Rebecca; Benhamou, Raphael I.; Jaber, Qais Z; Dorot, Orly; Louzoun Zada, Sivan; Oved, Keren; Pichinuk, Edward; Fridman, Micha. European Journal of Medicinal Chemistry, 2019, 179, 779-790.

6.jpg

46. Guiding Drugs to Target- Harboring Organelles: Stretching Drug-Delivery to a Higher Level of Resolution. Louzoun Zada, Sivan; Jaber, Qais Z.; Fridman, Micha. Angewandte Chemie International Edition, 2019, 58, 2-13.

TOC ARTWORK.jpg

2018

45. Fluorescent Tracking of the Endoplasmic Reticulum in Live Pathogenic Fungal Cells. Benhamou, Raphael I.; Jaber, Qais Z.; Herzog, Ido M.; Roichman, Yael; Fridman, Micha. ACS Chemical Biology, 2018, 13, 3325-3332.

8.gif

44. Cationic Amphiphiles Induce Macromolecule Denaturation and Organelle Decomposition in Pathogenic Yeast. Jaber, Qais Z.; Benhamou, Raphael I.; Herzog, Ido M.; Ben Baruch, Bar; Fridman, Micha. Angewandte Chemie International Edition, 2018, 57, 16391-16395.

9.jpg

43. Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall. Louzoun Zada, Sivan; Green, Keith D.; Shrestha, Sanjib K.; Herzog, Ido M.; Garneau-Tsodikova, Sylvie; Fridman, Micha. ACS Infectious Diseases, 2018, 4, 1121-1129. 

10.jpeg

42. Localizing Antifungal Drugs to the Correct Organelle can Markedly Enhance their Efficacy. Benhamou, Raphael I.; Bibi, Maayan; Berman, Judith; Fridman, Micha. Angewandte Chemie International Edition, 2018, 57, 6230-6235.

11.jpg

41. Bacterial-Derived Exopolysaccharides Enhance Antifungal Drug Tolerance in a Cross-Kingdom Oral Biofilm. Kim, Dongyeop; Liu, Yuan; Benhamou, Raphael I.; Sanchez, Hiram; Simón-Soro, Áurea; Li, Yong; Hwang, Geelsu; Fridman, Micha; Andes, David R.; Koo, Hyun. ISME Journal, 2018, 12, 1427–1442.

40. Increased Degree of Unsaturation in the Lipid of Antifungal Cationic Amphiphiles Facilitates Selective Fungal Cell Disruption. Steinbuch, Kfir B.; Benhamou, Raphael I.; Levin, Lotan; Stein, Reuven; Fridman, Micha. ACS Infectious Diseases, 2018, 4, 825-836.

12.jpeg

2017

39. Tuning the Effects of Bacterial Membrane Permeability through Photo-Isomerization of Antimicrobial Cationic Amphiphiles. Salta, Joana; Benhamou, Raphael I.; Herzog, Ido M.; Fridman, Micha. Chemistry A European Journal, 2017, 23, 12724-12728.

13.jpg

38. Structural Insights of Lincosamides Targeting the Ribosome of Staphylococcus aureus. Matzov, Donna; Eyal, Zohar; Benhamou, Raphael I.; Shalev-Benami, Moran; Halfon, Yehuda; Krupkin, Miri; Zimmerman, Ella; Rozenberg, Haim; Bashan, Anat; Fridman, Micha; Yonath, Ada. Nucleic Acids Research, 2017, 45, 17, 10284-10292.

37. The Role of Chemistry in Delivering the Next Antimicrobial Drugs. Fridman, Micha. Chem, 2017, 3, 8-14.

36. Real-Time Imaging of the Azoles-Class of Antifungal Drugs in Live Candida Cells. Benhamou, Raphael I.; Bibi, Maayan; Steinbuch, Kfir B.; Hamutal, Engel; Levin, Maayan; Roichman, Yael; Berman, Judith; Fridman, Micha. ACS Chemical Biology, 2017, 12, 1769−1777.

14.gif

35. Characterization of Non-Dialyzable Constituents from Cranberry Juice that Inhibit Adhesion, Co-Aggregation and Biofilm Formation by Oral Bacteria. Neto, Catherine; Penndorf, Kelsey A; Feldman, Mark; Meron-Sudai, Shiri; Rones, Zichria; Steinberg, Doron; Fridman, Micha; Kashman, Yoel; Ginsburg, Isaac; Ofek, Itshak; Weiss, Ervin. Food and Function, 2017, 8, 1955-1965.

15.gif

2016

34. Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation. Herzog, Ido M.; Louzoun Zada, Sivan; Fridman, Micha. Journal of Medicinal Chemistry, 2016, 59, 8008-8018.

20.gif

33. Phosphonium Pillar[5]arenes as a New Class of Efficient Biofilm Inhibitors: Importance of Charge Cooperativity and the Pillar Platform. Joseph, Roymon; Kaizerman, Dana; Herzog, Ido M.; Hadar, Maya; Feldman, Mark; Fridman, Micha; Cohen, Yoram. Chemical Communications, 2016, 52, 10656-10659. 

21.gif

32. Antifungal Imidazole-Decorated Cationic Amphiphiles with Markedly Low Hemolytic Activity. Benhamou, Raphael I.; Steinbuch, Kfir B.; Fridman, Micha. Chemistry A European Journal, 2016, 22, 1148-1151.

26.tif

31. Synthesis and Evaluation of Membrane Permeabilizing Properties of Cationic Amphiphiles Derived from the Disaccharide Trehalose. Shaul, Pazit; Benhamou, Raphael I.; Herzog, Ido M.; Louzoun Zada, Sivan; Ebenstein, Yuval; Fridman, Micha. Organic & Biomolecular Chemistry, 2016, 14, 3012-3015.

27.tif

30. Cationic Pillararenes Potently Inhibit Biofilm Formation without Affecting Bacterial Growth and Viability. Joseph, Roymon; Naugolny, Alissa; Feldman, Mark; Herzog, Ido M.; Fridman, Micha; Cohen, Yoram. Journal of the American Chemical Society, 2016, 138, 754-757.

28.gif

29. Mechanisms of Resistance to Membrane-Disrupting Antibiotics in Gram-Positive and Gram-Negative Bacteria. Steinbuch, Kfir B.; Fridman, Micha. MedChemComm, 2016, 7, 86-102.

29.tif

2015

28. Di-N-Methylation of Anti-Gram Positive Aminoglycoside-Derived Membrane Disruptors Improves Antimicrobial Potency and Broadens Spectrum to Gram Negative Bacteria. Benhamou, Raphael I.; Shaul, Pazit; Herzog, Ido M.; Fridman, Micha. Angewandte Chemie International Edition, 2015, 54, 13617-13621.

30.jpg

27. Exploring the Effects of Glycosylation and Etherification of the Side Chains of the Anti-Cancer Drug Mitoxantrone. Shaul, Pazit; Steinbuch, Kfir B.; Blacher, Eran; Stein, Reuven; Fridman, Micha. ChemMedChem, 2015, 10, 1528-1538.

30.png

26. One-Pot Chemoenzymatic Cascade for Labelling of the Epigenetic Marker 5-Hydroxymethylcytosine. Nifker, Gil; Levy-Sakin, Michal; Berkov-Zrihen, Yifat; Shahal, Tamar; Gabrieli, Tslil; Fridman, Micha; Ebenstein, Yuval. ChemBioChem, 2015, 16, 1857-1860.

31.jpg

25. Tobramycin and Nebramine as Pseudo-Oligosaccharide Scaffolds for Development of Antimicrobial Cationic Amphiphiles. Berkov-Zrihen, Yifat; Herzog, Ido M.; Feldman, Mark; Benhamou, Raphael I.; Steinbuch, Kfir B.; Shaul, Pazit; Lerer, Shachar; Eldar Avigdor; Fridman, Micha. Chemistry A European Journal, 2015, 21, 4340-4349.

32.tif

24. Targeting CD38 in the Tumor Microenvironment; a Novel Approach to Treat Glioma Cancer Cell and Microenvironment. Blacher Eran; Levy Ayelet; Ben Baruch Bar; Green Keith D.; Garneau-Tsodikova Sylvie; Fridman Micha; Stein Reuven. Cancer Cell & Microenvironment, 2015, 2, e486.

23. Inhibition of Glioma Progression by a Newly Discovered CD38 Inhibitor. Blacher, Eran; Levy, Ayelet; Geva, Nurit; Green, Keith D., Sylvie, Garneau-Tsodikova, Fridman, Micha; Stein, Reuven. International Journal of Cancer, 2015, 136, 1422-1433.

22. Antimycobacterial Activity of DNA Intercalator Inhibitors of Mycobacterium Tuberculosis Primase DnaG. Garneau-Tsodikova, Sylvie; Gajadeera, Chathurada; Willby, Melisa; Green, Keith; Shaul, Pazit; Fridman, Micha; Posey, James; Oleg Tsodikov. Journal of Antibiotics, 2015, 68, 153-157.

2014

21. Design and Synthesis of Membrane-Targeting Antibiotics: from Peptides to Aminosugar-Based Antimicrobial Cationic Amphiphiles. Herzog, Ido M.; Fridman, Micha. MedChemComm, 2014. 5, 1014-1026.

11.tif

2013

20. Design of Membrane Targeting Tobramycin-Based Cationic Amphiphiles with Reduced Hemolytic Activity. Herzog, Ido M.; Feldman, Mark; Eldar-Boock, Anat; Satchi-Fainaro, Ronit; Fridman, Micha. MedChemComm, 2013, 4, 120-124.

34.gif

19. The Structure of Anthracycline Derivatives Determines Their Subcellular Localization and Cytotoxic Activity. Shaul, Pazit; Frenkel, Michael; Briner-Goldstein, Elinor; Mittleman, Leonid; Grunwald, Assaf; Ebenstein, Yuval; Tsarfati, Ilan; Fridman, Micha. ACS Medicinal Chemistry Letters, 2013, 4 (3), 323–328.

35.gif

18. Di-alkylated Paromomycin Derivatives: Targeting the Membranes of Gram-Positive Pathogens that Cause Skin Infections. Berkov-Zrihen, Yifat; Herzog, Ido M.; Feldman, Mark; Sonn-Segev, Adar; Roichman, Yael; Fridman, Micha. Bio-Organic & Medicinal Chemistry, 2013, 4 (3), 3624–3631.

36.jpg

17. Synthesis and Evaluation of Hetero- and Homo-dimers of Ribosome-Targeting Antibiotics: Antimicrobial Activity, in vitro Inhibition of Translation, and Drug Resistance. Berkov-Zrihen, Yifat; Green, Keith D.; Labby, Kristin J.; Feldman, Mark; Garneau-Tsodikova, Sylvie; Fridman, Micha. Journal of Medicinal Chemistry, 2013, 56 (13), 5613-5625.

40.gif

16. Site-Selective Displacement of Tobramycin Hydroxyls for Preparation of Antimicrobial Cationic Amphiphiles. Berkov-Zrihen, Yifat; Herzog, Ido M.; Feldman, Mark; Fridman, Micha. Organic Letters, 2013, 15(24), 6144-6147.

41.gif

2012

15. Acylation of Novobiocin by Carboxylic-Acid Anhydrides: Preparation and Characterization of Semi-Synthetic Novenamines. Berkov-Zrihen, Yifat; Rutenberg, Roi; Fridman, Micha. Tetrahedron, 2012, 68(10), 2306–2312.

43.tif

14. 6"-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes. Herzog, Ido M.; Green, Keith D.; Berkov-Zrihen, Yifat; Feldman, Mark; Vidavski, Roee R.; Eldar-Boock, Anat; Satchi-Fainaro, Ronit; Eldar, Avigdor; Garneau-Tsodikova, Sylvie; Fridman, Micha. Angewandte Chemie International Edition, 2012, 51, 5652-5656.

44.JPG

2011

13. Assessment of 6'- and 6'''-N-acylation of Aminoglycosides as a Strategy to Overcome Bacterial Resistance. Shaul, Pazit; Green, Keith D.; Rutenberg, Roi; Kramer, Maria; Berkov-Zrihen, Yifat; Breiner-Goldstein, Elinor; Garneau-Tsodikova, Sylvie; Fridman, Micha. Organic & Biomolecular Chemistry, 2011, 9(11), 4057-4063.

10.gif

12. Targeting Anthracycline Resistant Tumor Cells by Synthetic Aloe-emodin Glycosides. Breiner-Goldstein, Elinor; Evron, Zoharia; Frenkel, Michael; Cohen, Keren; Peer, Dan; Nir Meiron, Keren; Roichman, Yael; Flescher, Eliezer; Fridman, Micha. ACS Medicinal Chemistry Letters, 2011, 2(7), 528-531.

44.jpeg

2010

11. Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides. Green, Keith D.; Chen, Wenjing; Houghton, Jacob L.; Fridman, Micha; Garneau-Tsodikova, Sylvie. ChemBioChem, 2010, 11(1), 119-126.

45.gif

2009

10. hChAT: A Tool for the Chemoenzymatic Generation of Potential Acetyl/Butyrylcholinesterase Inhibitors. Green, Keith D.; Fridman, Micha; Garneau-Tsodikova, Sylvie. ChemBioChem, 2009, 10(13), 2191-2194.

46.jpg

9. Using Biological Performance Similarity to Inform Disaccharide Library Design. Tanikawa, Tetsuya; Fridman, Micha; Wagner, Bridget K.; Zhu, Wenjiang; Faulk, Brian; Joseph, Isaac C.; Clemons, Paul A.; Kahne, Daniel. Journal of the American Chemical Society, 2009, 131(14), 5075-5083.

47.gif

2008

8. Behaviour of the azido group in crystal structure of the intermediates of aminoglycoside antibiotics. Botoshansky, Mark; Nudelman, Igor; Fridman, Micha; Belakov, Valery; Baasov, Timor*. Acta Crystallographica Section A: Foundations and Advances. 2008, 64(28), C381.

2007

7. Chemoenzymatic Formation of Novel Aminocoumarin Antibiotics by the Enzymes CouN1 and CouN7. Fridman, Micha; Balibar, Carl J.; Kahne, Daniel; Walsh, Christopher T.; Garneau-Tsodikova, Sylvie. Biochemistry, 2007, 46(28), 8462-8471.

48.gif

6. Characterization of Rhodosaminyl-Transfer by the AknS/AknT Glycosylation Complex and its Use in Reconstituting the Biosynthetic Pathway of Aclacinomycin A. Leimkuhler, Catherine; Fridman, Micha; Lupoli, Tania; Walker, Suzanne; Walsh, Christopher T.; Kahne, Daniel. Journal of the American Chemical Society, 2007, 29(34), 10546-10550.

49.jpeg

2005

5. Dual Effect of Synthetic Aminoglycosides: Antibacterial Activity Against Bacillus Anthracis and Inhibition of Anthrax Lethal Factor. 

Fridman, Micha; Belakhov, Valery; Lee, Lac V.; Liang, Fu-Sen; Wong, Chi-Huey; Baasov, Timor. Angewandete Chemie International Edition, 2005, 44(3), 447-452.

4. Branched Aminoglycosides: Biochemical Studies and Antibacterial Activity of Neomycin B Derivatives. Mairiana; Pokrovskaya, Varvara; Shallom-Shezifi, Dalia; Fridman, Micha; Belakhov, Valery; Shahar, Dina; Yaron, Sima; Baasov, Timor. Bioorganic & Medicinal Chemistry, 2005. 13(20), 5797-5807.

50.jpg

2003

3. A New Class of Branched Aminoglycosides: Pseudo-Pentasaccharide Derivatives of Neomycin B. Fridman, Micha; Belakhov, Valery; Yaron, Sima; Baasov, Timor. Organic Letters, 2003, 5(20), 3575-3578.

51.gif

2002

2. One-Pot Synthesis of Glucosamine Oligosaccharides. Fridman, Micha; Solomon, Dmitry; Yogev, Shay; Baasov, Timor. Organic Letters, 

2002, 4(2), 281-283.

52.jpeg

2001

 1. A Synthetic Pentasaccharide with GTPase Activity. Solomon, Dmitry; Fridman, Micha; Zhang, Jeanwei; Baasov, Timor . Organic Letters,

 2001, 3(26), 4311-4314.

53.gif

BOOKS & BOOK CHAPTERS

Synthesis of aminoglycosides, Berkov-Zrihen, Yifat; Fridman, Micha. Modern Synthetic Methods in Carbohydrate Chemistry: From Monosaccharides to Complex Glycoconjugates. Wiley-VCH, 2013.

bottom of page